For the first time, researchers plant identifier have succeeded without the help of gene and protein alone, "reprogram" the cells into pluripotent stem cell research and so-called "protein - induced pluripotent stem cells" (PDF. IP. Sought. S.)
Researchers at the California Institute Askryps management "Sheng Ding," could, in a new way, through a combination of only a few proteins in mouse skin cells, causing the cells to reprogram stem cells "PDF. IP. Sought. S." achieve.
The results of their research plant identifier in the Journal Stem cell researchers plant identifier (thirty. Feed. Thirty.) Has been released for import of proteins into mouse cells of a short protein (peptide) protein was used to bind and transport through the cell membrane is possible.
While all research groups worldwide have four specific genes to reprogram cells injected directly into the Ding and his colleagues have used the proteins are usually gene in cells are define. Because these proteins are large molecules, researchers had a special way of assimilating plant identifier them into the cells. plant identifier
Researchers do this, several molecules of amino acid "arginine" as an "entry card" attached to the protein sequence and arginine to absorb large molecules in cells are helped and reception. Researchers, these proteins were produced in bacteria and Ding and colleagues for their experiments using mouse embryonic skin cells and make them four times with a mixture of proteins "he. C,. T. 4 '", do . I.. F. 0.4 "," s. to him. x 2 ", and" c - i. Absylvn. thirty. " plant identifier Placed in contact. plant identifier
Biomedical scientists at the Max Planck Institute for Molecular German city of Munster in mouse embryo fibroblast plant identifier cells were Askryps of his colleagues at the Institute in order to test the quality, versatility and pleural cells take Potent this organization "re-programmed" by .
Modern biochemical methods to reprogram cells, easier and safer than ever in all the ways that this relationship existed. This scientific breakthrough is an important advance in order to produce plant identifier stem cells without the risk of cancer in the future that could have a significant role to play.
The German scholar of the cells produced were really property specific pluripotent stem cells, says tests show an interesting transition installation of genes in mouse cells with the virus is not necessary and combination The mixture of proteins with a "molecule" short enough to be done reprogram cells. This short molecule, a small chemical molecules that installation and connection of hereditary protein carries genetic information "DVD. NPT. Them." Makes it easy. Meanwhile in ways that far at the international level has been common gene transfer special planned again ("C - I. Absylvn. Thirty.", "S. To him. X 2", "him. Thirty. T 0.4 "and" Ka. L.. F-4 ") to the target cell is necessary.
Based on Schuler said, while genetically modified cells can be inactivated or transformed cells may lead to other genes, but based on today's plant identifier knowledge, adding protein to DNA does not have any high risk.
Potent induction of pleural cells (including IP. Sought. Feed., And PDF. IP. Sought. S..) Can both cell types, including neurons or liver cells become in the future to treat conditions such as Parkinson's and diabetes or restore neural connections in people with spinal cord injury, for example, can play an important role. Scientists no longer an important part of the analysis of these cells in disease emergence know.
The German researchers said the jump method is not genetic and there is no concern. In conventional tests, or pleural Potent characteristic pluripotency of these cells has been confirmed. Injection of these cells into mouse embryos also making cotyledon or three basic ones (Antvdrm, mesoderm and ectoderm) during the growth of the fetus, all organs and tissues are made.
However, for large molecules, proteins plant identifier needed to reprogram yet but it seems that the main problem is to solve the cell re-programmed by the Schuler says planning of the re now can cells without the need of "CD. NPT. them." As a result of genetic mutations do not occur suddenly and are not of concern.
Researchers should consider the next steps for each cell type, a mixture of compounds that can be sprayed onto the stem cells to be produced by the cells of these compounds have required a cell. For example, researchers have been successful pleural Potent induction of stem cells, neurons and heart muscle grow.
Professor "Wolfgang Franz Michael" Grvs hadrn research university clinic in Munich, Germany as a great new way to make stem cells and joy and said, this is a very important change in the re-planning cells.
Due to these improvements, the doctor thought plant identifier that physicians in the 2020 filing with a minor surgical plant identifier procedure to remove some of the skin of the patient's arm and asking the patient a week later to refer to the treatment of diabetes . The patient's skin biopsy culture and physician assistants are added to a mixture of chemicals and
